The S&P/ASX 200 Index (ASX: XJO) has fallen further this week as investor sentiment continues to deteriorate.
Ongoing conflict between the US and Iran is driving fresh concerns about restricted oil supply and inflation, and the renewed fears about further interest rate hikes are spooking investors.
Let's find out how the shift in sentiment is affecting major ASX 200 shares like Domino's Pizza Enterprises Ltd (ASX: DMP), Telix Pharmaceuticals Ltd (ASX: TLX), and Wesfarmers Ltd (ASX: WES), and what brokers tip next.
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Buy Telix Pharmaceuticals shares
Telix shares have rocketed over 10% higher in Tuesday afternoon trade to $17.99 apiece. Today's increase means the shares are now up 58% year to date.
Today's increase comes on the back of yesterday's news that its brain cancer imaging drug, Pixclara, has received approval from the US FDA. This makes it the first FET-PET imaging drug cleared for use in glioma and expands Telix's precision medicine portfolio.
Telix says Pixclara is already the subject of a Phase 3 trial for diagnosis in additional brain conditions, with potential expansion to brain metastases.
The company said it plans to target market leadership in both imaging and treatment for several high-need cancers.
Telix's broader pipeline includes late-stage assets in prostate, kidney, and glioblastoma cancers, with a focus on bringing further precision medicine products to both existing and new markets worldwide.
Investors were clearly thrilled with the news, and many are rushing to snap up the shares.
Analysts are very bullish on the outlook for the stock, too. Market Index data shows the majority of brokers have a buy rating on the shares, and even after today's share price spike, the $24.68 average target price implies there is potential for about 37% upside ahead.
Hold Domino's Pizza shares
Domino's Pizza shares have climbed higher on Tuesday afternoon, up around 1% to $19.14 a piece at the time of writing. The shares are still down 12% year to date.
It's been a volatile month for the pizza operator. Its share price fell around 6% after the food operator announced its FY26 results, including a 11.2% decrease in revenue, and a statutory NPAT loss of $134.2 million. It also announced $255.7 million in non-cash write-downs and impairments.
Domino's underlying NPAT was up 4% for the 12-month period, and in line with guidance, but EBITDA fell 6.1%. The company also cut its total FY26 dividend by 25.3% to 57.5 cents.
Going forward, Domino's said it is planning to return to profitable growth in FY27 after a period of resetting its store network and business model.
But it looks like the experts are on the fence about whether this growth can come to fruition. Market Index data shows the majority of brokers have a hold rating on the ASX shares. The $20.10 average target price implies an upside of around 5% at the time of writing.
Sell Wesfarmers shares
Wesfarmers shares are in the red at the time of writing, down around 0.5% to $72.42 each. The shares have crashed by around 22% since late July and are now down 11% for the year to date.
The shares were pushed lower in August amid broad pressure on consumer and retail stocks, as well as concerns about inflation and interest rate increases.
The sell-off also picked up pace after the conglomerate posted its FY26 results in late August.
The company reported a 3.4% increase in revenue to $47.3 million and a 7.3% increase in EBIT. But statutory NPAT fell 1.8% to $2.8 million, including significant items, or was up 8.3% excluding them.
Going forward, Wesfarmers said it expects higher capital expenditure in FY27, of $1.3 billion to $1.5 billion.
But investors were spooked, potentially because, although the result was robust, it raises questions about how the business can continue to grow in a weakening market.
Brokers are concerned, too. Market Index data shows the majority now have a strong sell rating on Wesfarmers shares. After the latest price crash, the $77 average target price implies around a 6% upside at the time of writing.
