It has been a modest year for the S&P/ASX 200 Index (ASX: XJO) in 2025, with an approximate gain of 6%. ASX materials and defence shares have been a real winner thanks to soaring commodity prices and global defence investment.
On the flip side, it's been a tough year for Australian technology and healthcare shares.
The S&P/ASX All Technology Index (ASX: XTX) has dropped almost 11% in 2025, including more than 20% since October.
Similarly, the S&P/ASX 200 Health Care Index (ASX: XHJ) is down more than 24% since January.
But amidst these struggling sectors have been some diamonds in the rough.
Let's look at some of the winners from these two sectors in 2025.
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Healthcare winners
One of the best performing ASX shares in 2025 has been 4DMedical Ltd (ASX: 4DX).
The medical technology company works in the field of respiratory imaging and ventilation analysis in the treatment of lung and respiratory diseases.
The Motley Fool's Aaron Teboneras reported earlier this month on the consistent run of positive results and milestones hit by the company this year.
Regulatory approvals and new commercial partnerships have expanded its markets and validated its technology, shifting investor views from speculative potential to increasingly visible and growing software revenue.
This has launched the stock almost 680% higher in 2025.
Despite this unbelievable run, it's still drawing optimism for future growth.
Another healthcare stock winner this year has been Racura Oncology Ltd (ASX: RAC).
It is an Australian clinical-stage biopharmaceutical company focused on developing cancer treatments.
It has risen almost 100% in 2025, meaning investors almost doubled their returns holding this stock through the year.
This has been driven by promising scientific research and private placement offers.
Technology winners
Meanwhile, in the technology sector, one of the best-performing ASX shares has been Elsight Ltd (ASX: ELS).
The company technically sits in the information technology sector, but has risen thanks to tailwinds in the defence sector.
The company offers advanced communication components for unmanned systems (aerial, ground, and sea) through its flagship product – the Halo platform.
Its rise has been fuelled by major contract wins, including a US$21.2M contract for CY2026.
CY25e also marked a pivotal inflection point for the company, achieving profitability and delivering estimated revenue growth of 12x YoY (BPe).
Its share price has risen by more than 750% this year.
Finally, another technology stock that has enjoyed a stellar year is Energy One Ltd (ASX: EOL).
It is a supplier of software products and services to wholesale energy, environmental, and carbon trading markets.
It reported strong growth in the 2025 financial year, reporting revenue growth of 17% to $61.4 million and annual recurring revenue (ARR) rising 22% to $60.4 million.
Its share price is up more than 150% this year.
