3 Australian stocks that are my best buy and holds for 2026

These three stocks could be destined for big things in the future.

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Buying and holding shares is rarely comfortable at the moment you make the decision.

The best long-term opportunities often appear when sentiment is weak and patience is required. Right now, a number of high-quality Australian stocks are out of favour, not because their long-term prospects have vanished, but because markets are focused on short-term uncertainty.

For investors willing to look beyond today's headlines, these three stocks stand out as top buy and hold candidates for 2026.

CSL Ltd (ASX: CSL)

The first Australian stock I would be happy to buy and hold in 2026 is biotech CSL.

CSL shares have been under pressure for several reasons, which has tested investor patience. One source of frustration has been CSL Behring, the plasma therapies division that underpins the company's long-term growth story. Margin recovery has been slower than expected, which has weighed on its earnings growth.

At the same time, the Seqirus vaccines business has been impacted by weaker-than-expected influenza vaccination rates in the United States, leading management to temper near-term expectations. In addition, softer demand in China for albumin products hasn't helped matters.

Taken together, these issues have created a perfect storm of disappointment, even though none of them fundamentally undermine CSL's long-term position. Demand for plasma therapies continues to grow, investments in its plasma collections are yielding stronger results, and CSL's global scale and scientific expertise are unchanged.

For patient investors, the current sell-off looks like a great opportunity to build a position at a very attractive price.

WiseTech Global Ltd (ASX: WTC)

Another Australian stock that could reward long-term holders is WiseTech Global.

WiseTech shares have been caught up in a brutal tech selloff today, falling around 8%, as investors rotate away from growth stocks amid concerns over AI software disruption.

This could prove to be a huge overreaction. The company's CargoWise platform remains deeply embedded in global freight forwarding and logistics operations. As supply chains become more complex and compliance-heavy, the value of integrated software like this increases rather than diminishes.

The company continues to reinvest aggressively, which can make short-term results volatile. But for buy and hold investors, WiseTech's long runway and global expansion strategy remain firmly intact.

Xero Ltd (ASX: XRO)

A final Australian stock I would buy and hold into 2026 is Xero.

Xero has also been swept up in today's tech selloff, with its shares down roughly 12% as investors weigh up the threat of AI on software providers.

Interestingly, only yesterday Xero spoke about how it believes AI is not going to disrupt its business model. In fact, it thinks it will be a winner from AI. It stated that "Xero is well positioned to capitalise on the AI TAM expansion opportunity, leveraging our advantages as a system of record."

This could make today's selloff a great opportunity for patient buy and hold investors.

Motley Fool contributor James Mickleboro has positions in CSL, WiseTech Global, and Xero. The Motley Fool Australia's parent company Motley Fool Holdings Inc. has positions in and has recommended CSL, WiseTech Global, and Xero. The Motley Fool Australia has positions in and has recommended WiseTech Global and Xero. The Motley Fool Australia has recommended CSL. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

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