Commonwealth Bank of Australia (ASX: CBA), Paladin Energy Ltd (ASX: PDN), and CSL Ltd (ASX: CSL) shares are closing out a week to forget.
With only half a day of trade left before Friday's closing bell, the S&P/ASX 200 Index (ASX: XJO) is down 1.3% for the week.
Here's how these three ASX 200 heavyweights are faring over this same time:
- CBA shares are down 8.7% at $160.58 each
- Paladin Energy shares are down 15.3% at $10.58 each
- CSL shares are down 17.9% at $98.46 each
Ouch!
Here's what had investors reaching for their sell buttons this week.

Image source: Getty Images
CSL shares smashed on guidance cut
Most of the pain for CSL shares was delivered on Monday.
The ASX 200 biotech stock closed the day down a sharp 16% following the release of a trading update, based on a 90-day review by CSL's interim CEO Gordon Naylor.
Investors were clearly displeased with the lowered full-year FY 2026 revenue and profit expectations.
"Our growth initiatives are working, but the financial benefits will take longer than previously anticipated to materialise. As a result, we have now revised down our 2026 financial year guidance," Naylor said.
CSL said it expects FY 2026 revenue of around US$15.2 billion on a constant currency basis, down from US$15.6 billion in FY 2025. And the biotech giant is forecasting net profit after tax and amortisation (NPATA) of around US$3.1 billion, excluding restructuring costs and impairments. That's down from US$3.3 billion the previous year.
Paladin Energy shares slammed on cash outflows
Unlike CSL shares, Paladin Energy took a hit this week despite reporting increasing profits.
Shares in the ASX 200 energy stock closed down 12.1% on Wednesday on the heels of its March quarter update.
Highlights included a 51.3% year-on-year increase in revenue for the nine months to 31 March, to US$209.1 million.
And Paladin Energy swung back into profit, reporting a net profit after tax (NPAT) of US$1.7 million, up from a loss of US$30.1 million in the prior corresponding nine-month period.
However, investors may have been concerned by the nine-month operating cash outflow of US$36.4 million, down from a cash inflow of US$14 million in the prior corresponding period.
Which brings us to…
CBA shares hit on profit decline
Joining Paladin Energy and CSL shares in the ASX doghouse this week, CBA shares closed down 10.4% on Wednesday after the ASX 200 bank released its March quarter results (Q3 FY 2026).
Although the big four bank achieved an unaudited quarterly cash net profit after tax (NPAT) of around $2.7 billion, that was down 1% on CBA's first-half cash quarterly NPAT average.
Investors also reacted unfavourably to the uncertainty facing the Aussie economy and the bank in the months ahead.
CBA CEO Matt Comyn said:
Conflict in the Middle East is disrupting critical supply chains and contributing to global uncertainty…
Notwithstanding an already strong level of provisioning, we have chosen to further top up our collective provisions in the quarter to reflect heightened macroeconomic risks.