These speculative ASX stocks could rise 90% to 140%

These high risk shares could deliver high rewards according to analysts.

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Key points

  • Epiminder is positioned to revolutionise epilepsy management with its Minder system, targeting a significant US market and planning a phased commercial launch, with analysts predicting a potential 96% upside.
  • Chalice Mining's Gonneville Project is highlighted for its strategic importance and robust development plan, with Bell Potter seeing substantial upside of 140%, supported by potential government-backed funding.
  • Both companies are regarded as speculative buys offering high-risk, high-reward opportunities, with significant development plans and market potential in their respective fields.

If you have a high tolerance for risk, then you may want to check out the speculative ASX stocks listed below.

That's because they could be destined to deliver huge returns for investors over the next 12 months according to analysts. Here's what they are recommending to clients:

Epiminder Ltd (ASX: EPI)

This newly listed medical device and information solutions company could be an ASX stock to buy according to Morgans.

It believes the company's epilepsy diagnosis and management system is well-placed in a market estimated to be worth US$1.1 billion in just the United States. It said:

Epiminder (EPI) aims to transform epilepsy diagnosis and management through the Minder system, the first FDA-approved sub-scalp EEG capable of continuous brain monitoring for months or years. Unlike current short-duration EEG tests, Minder provides long-window, high-fidelity that enables more accurate diagnosis and better treatment decisions. EPI is targeting a phased US commercial launch in 2H26.

EPI's initial focus is drug-resistant epilepsy (DRE) patients with inconclusive EEG results, a segment representing up to 45,000 patients annually in the US and a US$1.1bn market opportunity. IPO proceeds will fund completion of the DETECT demonstration study, development of the next-generation G1 Minder® system, and initial build-out of US commercial infrastructure. Key near-term catalysts include the targeted 2H26 release of the G0 device and start of the DETECT study.

Morgans has initiated coverage with a speculative buy rating and $2.33 price target. Based on its current share price of $1.19, this suggests that upside of 96% is possible between now and this time next year.

Chalice Mining Ltd (ASX: CHN)

Over at Bell Potter, its analysts see huge potential returns on offer with this mineral exploration company's shares.

The broker was pleased with the pre-feasibility study (PFS) for the 100%-owned Gonneville Palladium-Nickel-Copper Project. It believes it positions Gonneville as a globally significant, long-life, low-cost critical minerals project with an improved and simplified development plan. It said:

CHN has outlined a development plan for Gonneville that positions it as a globally significant, long-life, low-cost critical minerals project that is a close strategic fit with western government objectives to diversify, de-risk and secure critical minerals supply chains. This is a materially improved and simplified development plan with reduced upfront costs compared with the original hydrometallurgical circuit.

The PFS delivers strong production and financial metrics at cyclically low prices and demonstrates high leverage to rising commodity prices. These are all factors we believe will support Gonneville's development and attract a significant amount of government backed debt funding. This will likely carry relatively low service costs, relatively long maturity dates and leave a relatively small equity funding requirement, in our view. Optionality to extend the mine life into a multi-generational asset strengthens the funding case further.

In response, Bell Potter has retained its speculative buy rating with a trimmed price target of $4.00. Based on its current share price of $1.64, this implies potential upside of 140% for investors.

Motley Fool contributor James Mickleboro has no position in any of the stocks mentioned. The Motley Fool Australia's parent company Motley Fool Holdings Inc. has no position in any of the stocks mentioned. The Motley Fool Australia has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

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