3 ASX stocks with significant US exposure

Looking for exposure to the US economy through ASX investing? Here's three options to consider. 

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Wrapping your head around investing can take a little bit of time. One important factor is that some ASX stocks are influenced by international economies such as the US. 

For example, industries like technology and international travel are dependent on the conditions of global markets. 

The U.S. economy has historically influenced Australia by shaping investor sentiment, interest rates, and global capital flows, which significantly impact ASX stock valuations and market performance. 

If you are looking to have exposure to the US market, while investing in ASX listed companies, here are three to consider. 

CSL Ltd (ASX: CSL)

CSL Limited is one of the world's largest biotech companies, primarily focused on developing and delivering biotherapies and influenza vaccines. 

It is a blue-chip ASX stock and currently its as the third largest company on the ASX by market capitalisation. 

However, it has fallen 13.12% year to date. 

The company operates mainly through two major divisions:

  • CSL Behring: Specialises in plasma-derived therapies (treatments for rare and serious diseases)
  • Seqirus: One of the world's largest influenza vaccine businesses.

CSL is heavily exposed to the U.S. market because the United States is its largest revenue source through plasma collection, biotherapy demand, and vaccine sales.

For example, CSL Behring operates one of the largest networks of plasma collection centers in the U.S. (over 300 centres), critical for its plasma-derived therapies.

Experts are tipping that, despite market pessimism, now could be a time to buy this ASX stock.

Goldman Sachs recently put a buy rating and $307.30 price target on CSL shares. 

Bell Potter has a Target Price of $315.02, indicating a 28.95% upside. 

Reliance Worldwide Corp Ltd (ASX: RWC)

Another ASX stock with US exposure that has had a rough 2025 so far is Reliance Worldwide.

The company is a water technology business that designs, manufactures, and supplies water delivery, control, and optimisation systems. Its share price is down 18.70% year to date. 

It is significantly exposed to the U.S. due to its strong presence in the plumbing and water control industry, with the U.S. being its largest geographical market.

The U.S. is a key driver of its sales, especially in residential plumbing and commercial infrastructure projects. 

Similar to CSL, brokers seem optimistic on the future for RWC shares. 

Bell Potter currently has a target price of $5.66, which indicates a 37.05% upside. 

Earlier this month, Goldman Sachs put a buy rating and $6.00 price target on the ASX stock.

Corporate Travel Management Ltd (ASX: CTD)

Corporate Travel Management provides business travel management services, across corporate travel, meetings and events, leisure, and loyalty programs.

The company operates across Australia and New Zealand, North America, Asia and Europe. 

Its share price has fallen just over 6% to start the year. 

Despite operating across multiple continents, the US sector serves as its largest revenue contributor, reporting revenue and other income of $311.5 million in FY24. 

Brokers believe there is a strong upside for this ASX stock.

Bell Potter currently has a target price of $17.48 on CTD shares which indicates an upside of 40.40%. 

Earlier this month, Morgan Stanley placed an overweight rating and $18.30 price target on its shares.

Motley Fool contributor Aaron Bell has no position in any of the stocks mentioned. The Motley Fool Australia's parent company Motley Fool Holdings Inc. has positions in and has recommended CSL, Corporate Travel Management, and Reliance Worldwide. The Motley Fool Australia has positions in and has recommended Corporate Travel Management. The Motley Fool Australia has recommended CSL. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

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