This fund returned 109% in 2024. Here are 2 of its best-performing ASX shares

Small caps proved to be the winners last year.

| More on:
A group of businesspeople clapping.

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More

When you're looking for the best ASX shares to add to your portfolio, sometimes it's helpful to let others do the heavy lifting.

This is where investment funds come into play, and based on one fund manager's results last year, the results can speak for themselves.

Investment firm Pengana's high-conviction equities strategy delivered an eye-popping 109% return in 2024. As reported by The Australian Financial Review, this puts it at the top spot among Australian investment funds for the year.

The fund credited much of this success to two standout performers: IperionX Ltd (ASX: IPX) and Clarity Pharmaceuticals Ltd (ASX: CU6).

These small-cap stocks drove the fund's gains last year, so they are worth a closer look for investors hunting for the best ASX shares in 2025. Let's see.

Pengana's best ASX shares

Pengana's high-conviction strategy focuses on small-cap stocks. As the AFR reported, portfolio manager James McDonald explained that smaller listed companies often offered greater opportunities than their large-cap counterparts.

The large-cap market is really tough, and we've just seen so many funds underperform the benchmark. I'm so glad that's not an area that we're fighting in.

There's just enormous opportunities in small companies, if you do your homework, to find great bargains.

Meanwhile, Wilson Asset Management says that small caps can outperform due to "reversion back to historical average multiples".

"Another way small caps can outperform is through earnings growth", it adds.

For Pengana, titanium producer IperionX was its largest holding in 2024 and a key driver of its outperformance.

According to the fund's most recent shareholder letter, IperionX was its best ASX share in December, when it surged 25% after fund manager Regal Funds increased its stake.

A glance at Pengana's September letter talked of the tailwinds from IperionX's contract win with vehicle giant Ford.

The initial contract size is modest at USD11 million but has the potential to increase in time as Ford adds more models and parts.

We view this very positively, validating the company's ability to supply commercial quantities of high value added components that sell at much higher prices than powder. The company has previously announced other development customers such as Lockheed Martin and GKN which we hope will also be converted to commercial contracts in the future.

Clarity Pharma adds to gains

Clarity Pharmaceuticals is a biotech company currently investigating a range of potential cancer therapies.

It delivered exceptional gains for Pengana in 2024, making it one of the best ASX shares for the period. They had reportedly increased by as much as 300% for the fundie at one point last year.

Clarity shares exploded in May after the company reported positive results from another clinical study investigating its treatment in prostate cancer. As my colleague James reported, shares were up 10% on the day alone.

Pengana also noted the results from Clarity's SECURE prostate cancer study in its September fund letter as well.

It expects another 14 patients to be dosed as part of the study throughout early 2025.

But Clarity wasn't Pengana's best ASX share for the latter half of the year, nor any shareholder's for that matter.

After peaking at $8.79 apiece in September, it closed the year at $4.17 apiece. This is a 47% decline from the mountain's peak.

The stock is still up more than 68% in the past year, even after this rapid decline.

Foolish takeout

These two stocks were some of the best ASX shares for Pengana's high-conviction equities fund last year.

Whether or not they will provide the same level of opportunity this year, only time will tell.

Both stocks have held substantial gains over the past 12 months, despite recent selling activity.

Motley Fool contributor Zach Bristow has no position in any of the stocks mentioned. The Motley Fool Australia's parent company Motley Fool Holdings Inc. has no position in any of the stocks mentioned. The Motley Fool Australia has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

More on Healthcare Shares

Excited couple celebrating success while looking at smartphone.
Healthcare Shares

Up 680% since July, here's why 2025 was a breakout year for this hot ASX stock

With consistent contract wins, FDA clearance, and backing from Pro Medicus, 4D Medical is showing that there is a commercial…

Read more »

Shot of a senior scientist looking stressed out while working in a lab.
Healthcare Shares

After soaring 40% in 2 weeks, this ASX All Ords healthcare stock has been downgraded

Here’s what analysts at Macquarie rate the stock as now.

Read more »

A little boy, soon to be a brother, kisses and holds his mum's pregnant tummy.
Healthcare Shares

Own NIB shares? Here are the key dates for 2026

NIB has released its corporate calendar, including dividend dates, for 2026.

Read more »

A male doctor wearing a white lab coat shrugs his shoulders and holds his hands up in the air looking confused
Healthcare Shares

ASX healthcare stock debuts at a massive discount to its initial public offer price

Saluda Medical shares have had a difficult start to public life, trading well below the initial public offer price.

Read more »

Red buy button on an apple keyboard with a finger on it representing asx tech shares to buy today
Healthcare Shares

Why CSL shares now look 'massively oversold'

A leading investment expert says ASX investors have a rare chance to buy CSL shares at a discount.

Read more »

Scientists working in the laboratory and examining results.
Healthcare Shares

Which junior biotech's shares are flying on positive trial news?

This company's shares have surged higher after positive clinical trial results for its stroke treatment drug.

Read more »

Excited elderly woman on a swing.
Healthcare Shares

Guess which ASX 300 healthcare share is lifting off on $25 million news

The ASX 300 healthcare share is grabbing investor interest on Thursday. Let’s see why.

Read more »

Female scientist working in a laboratory.
Healthcare Shares

Doomed takeover bid for Mayne Pharma to come to an end

The Mayne Pharma takeover saga appears to be finally drawing to an end, with shareholders bearing the pain of the…

Read more »