Motley Fool Australia

Coronavirus vaccine trial adverse event was probably unrelated to treatment

gloved hand injecting coronavirus vaccine into person's arm
Image source: Getty Images

This article was originally published on All figures quoted in US dollars unless otherwise stated.

After reviewing the adverse event that caused AstraZeneca plc (NYSE: AZN) to pause the clinical trials of its coronavirus vaccine, AZD1222, an independent review determined there's nothing to worry about.

Or at the very least, there's not enough evidence to determine whether there is something to worry about.

"After independent review, these illnesses were either considered unlikely to be associated with the vaccine or there was insufficient evidence to say for certain that the illnesses were or were not related to the vaccine," the clinical trial organizers for the phase 2/3 U.K. clinical trial wrote in the participant-information sheet, which was updated on Friday.

The volunteers developed "unexplained neurological symptoms including changed sensation or limb weakness," which is a little more descriptive than simply calling it an "unexplained illness," as AstraZeneca did when it acknowledged that the clinical trials had been paused last week.

The U.K. clinical trials testing AZD1222 have restarted, but the 30,000-participant U.S.-based clinical trial remains on hold while the drugmaker waits for the monitoring committee for that study to sign off on restarting the study.

During its investor-day presentation yesterday, Pfizer Inc. (NYSE: PFE) said that there hadn't been any pauses in the clinical trials of its coronavirus vaccine, BNT162b2, which it is developing with BioNTech SE (NASDAQ: BNTX). Pfizer continuously monitors the safety data, and an independent data-monitoring committee (DMC) reviews the data weekly. Pfizer isn't privy to whether adverse events are in patients given the active vaccine or placebo, but the DMC gets unblinded data, so they can eliminate adverse events in patients receiving placebo as obviously not caused by the active vaccine.

This article was originally published on All figures quoted in US dollars unless otherwise stated.

These 3 stocks could be the next big movers in 2020

When investing expert Scott Phillips has a stock tip, it can pay to listen. After all, the flagship Motley Fool Share Advisor newsletter he has run for more than eight years has provided thousands of paying members with stock picks that have doubled, tripled or even more.*

In this FREE STOCK REPORT, Scott just revealed what he believes are the 3 ASX stocks for the post COVID world that investors should buy right now while they still can. These stocks are trading at dirt-cheap prices and Scott thinks these could really go gangbusters as we move into ‘the new normal’.

*Returns as of 6/8/2020

Brian Orelli, PhD and The Motley Fool Australia has no position in any of the stocks mentioned. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

Related Articles...